Research, innovation
Production
The domestic owners and experts of Celsus Natural Medicine Ltd.. and Aurel RX KFT. combine trace elements, vitamins, minerals and herbal extracts in their products, the health-preserving effects of which have been proven and recognized for centuries.
Thanks to the results of our many years of research, we were the first in the world to develop our Q1+Q10 product line, about which we receive several successful feedbacks.
Our Q1Q10 product line: Vital Q1+Q10, Szívünkért Q1+Q10, Premium Magnesium Q1+Q10 are available in the composition. Our products are trademarked.
We successfully manufacture and develop unique dietary supplement products for domestic pharmacies, organic stores, and drugstores.
We strive to use only natural raw materials in our products, and to present them to consumers in the best quality and in the best combination.
In addition to our own products, we have been developing unique, high-active ingredient content vitamin and dietary supplement products in powder, liquid, tablet or capsule form for our domestic and foreign clients for several years.
Our motto is to develop innovative products that meet current expectations for ourselves and our clients!
Innovation, Awards
WHAT DOES IT MEAN FOR A COMPANY TO BE MEASURED IN THE FIELD OF INTERNATIONAL INNOVATION?
On the initiative of the Business Development Portal, the 1st International Business Development Award was presented on September 13, 2013, and the special award was won by Celsus Natural Medicine Ltd.
WHAT IS THE INTERNATIONAL BUSINESS DEVELOPMENT AWARD?
On the initiative of the Business Development Portal, the 1st International Business Development Award was presented this year. The independent professional jury evaluated the top 3 winners and the 2 special award winners from among the Hungarian small and medium-sized enterprises that entered this year's competition. The artificial intelligence-based speech analytics product line of Nextent Zrt. was chosen as the most innovative business development of the year.
The Business Development Portal launched the International Business Development Award in 2013 with the aim of drawing attention to the most innovative small and medium-sized enterprises, as well as the importance of innovation and its positive effects on the economy. In addition, the organizers aim to enable the applicant companies to learn about the implementation and market launch of innovative ideas through the feedback provided during the audit, thereby increasing their competitiveness.
The special feature of the Business Development Award is that applicants can receive objective feedback on the strengths and areas for development of their processes related to the creation of business innovations within the framework of an innovation review.
The Award is a truly independent, professional initiative that presents the business development and business innovation results of a company or enterprise, whether it is called business development, business innovation, business development or other types of innovation. The Award is open to all organizations that are engaged in successful product development, service development, organizational development, business development or business innovation.
Entries could be submitted with a new product, new service, marketing innovation, innovation in corporate strategy, technological innovation, process innovation, new and innovative communication solution, organizational change that promotes market success (new organization, culture change, etc.) or a new business model.
The award ceremony on September 13, 2013 took place at the Design Terminal in Budapest. In the competition, which was announced for the first time, the first 3 winners and 2 special prize winners were evaluated by an independent professional jury.
The jury members were: Gábor Schwarz, Business Development and Sales Director of USTREAM, Csaba Bundik, Managing Director of EuroCham Vietnam Ltd. and Zoltán Fodor, Editor-in-Chief of the Business Development Portal.
István Szabó, Head of Department at the National Innovation Office, said: "We welcome any initiative that draws attention to the importance of innovation and helps to integrate innovation into the everyday thinking of domestic companies."
NADH is biologically listed as "coenzyme-1", if there is a deficiency, then there will be a lack of energy at the cellular level, which causes weakness and fatigue. If NADH is missing in the body, it is like a car running out of gas. The more NADH available in a cell, the more energy the cell can produce. Energy is stored in the Q1 molecule. When NADH reacts with oxygen, which is present in every cell, energy is produced in the form of ATP. Each NADH molecule leads to the formation of 3 ATP molecules. In other words, the NADH molecule has three times the energy capacity of an ATP molecule. In addition, NADH produces additional energy when it reacts with oxygen and water, forming nicotinamide (also known as vitamin B3) and ADP (adenosine diphosphate). All this means that NADH is, in today's everyday language, a "super-energy" substance.
This is considered the biochemical cause of many chronic diseases, such as cancer, rheumatoid arthritis, arteriosclerosis and immunodeficiency diseases. Fortunately, human cells have developed a system that can correct changes in genetic material. This system is also called simply the DNA repair system, which requires the full functioning of NADH to function.
So, the ability of coenzyme Q1 is to convert many other compounds into their active, effective, antioxidant form. NADH converts the used glutathione back into its effective antioxidant form. This form of glutathione can then convert vitamin C back to its active state. Vitamin C can then regenerate the used vitamin E and convert it back to its active form.
When the production of these neurotransmitters increases, cognitive performance also improves.
Some studies have shown that the production of dopamine and adrenaline is naturally enhanced by NADH. Therefore, NADH /Q1 can effectively strengthen memory. How can Q1 help?
1. It protects the liver from alcohol-induced damage. NADH is the activator of the enzyme that breaks down alcohol (alcohol dehydrogenase). This means that the more NADH is in our liver, the faster alcohol is broken down. In addition, NADH can increase the efficiency of the liver's enzyme functions, resulting in faster oxidation, a shorter time for alcohol to act, and less average liver damage.
NADH also protects against alcohol-induced inhibition of the sex hormone testosterone. Under the influence of alcohol, testosterone production is blocked, inhibited. In other words, the more alcohol someone drinks, the less desire they have for sex. In the presence of NAD, this alcohol-induced inhibition of testosterone production is reduced or eliminated.
2. NADH lowers cholesterol levels and blood pressure. In a double-blind study on animals (rats with congenital, spontaneous hypertension), NADH reduced cholesterol levels within eight weeks and blood pressure within eleven weeks. These preliminary animal studies suggest that NADH may also be able to reduce blood pressure and cholesterol levels in humans.
3. NADH inhibits the autoxidation of dopamine. The neurotransmitter dopamine is spontaneously oxidized in the body, especially in the brain – a phenomenon called autoxidation. This process is significantly more pronounced in older people. Since NADH can inhibit the autoxidation of dopamine, it is a useful tool in preventing or reducing damage to certain areas of the brain.
4. NADH can help delay the "cell death" and tissue degeneration that occurs with aging.
Clinical Studies
A few years ago, several studies and clinical trials were conducted on NADH, which yielded very remarkable results. The studies showed that NADH could be effective or promising in the treatment of several difficult-to-treat diseases, such as Parkinson's disease, chronic fatigue syndrome (CFS), Alzheimer's disease and depression.
Parkinson's disease with Q1
The symptoms of Parkinson's disease are caused by a deficiency of dopamine, one of the most important messengers in the central nervous system.
This neurotransmitter is responsible for muscle tone and strength, the ability to stay upright, sexual desire (libido) and emotional drive.
This dopamine deficiency is well reflected in the three most important symptoms of Parkinson's disease: akinesia (i.e. inability to move), rigidity and tremors (i.e. shaking). These symptoms should not be ignored if one is looking for a rational and effective treatment for Parkinson's disease, and life expectancy can be normal if appropriate treatment is used!
In a clinical open study, 885 patients with Parkinson's disease were treated with the only stabilized, absorbable, oral form of NADH. After two weeks of treatment, a significant number of patients experienced improvements in mobility, especially in walking, pushing, posture, speech and facial expressions.
NADH improves perception and comprehension (cognitive thinking). One FDA-approved, double-blind, placebo-controlled study conducted at Georgetown University Medical Center found that patients with dementia (mental decline) such as Alzheimer's disease showed statistically significant improvement after 6 months of treatment with 10 mg of NADH daily (taken as two 5 mg tablets). Patients treated with NADH showed no further evidence of progressive cognitive decline during the treatment period and experienced significant improvements in memory, verbal communication, and visual and perceptual problem-solving.
These results support the use of NADH as part of a treatment program for Alzheimer's disease. The results may reflect increased energy metabolism in damaged but still viable brain cells.
Does Q1 help with depression?
The absolute causes of depression are not yet fully understood, but an imbalance in neurotransmitters (specific chemicals in the nervous system such as dopamine, norepinephrine, and serotonin) plays a key role in depression, as NADH is known to stimulate the natural production of these neurotransmitters.
How it works: Researchers say that NADH is safe to take for long periods of time. Many people have taken NADH for years without experiencing any side effects. The body is constantly in a state of energy within the cells, as NADH is very efficient at supplying energy to the cells. So the more NADH the body has available, the more energy the body can produce. If someone is taking NADH therapeutically, then a continuous daily intake supplemented with the other coenzyme, Q10, is recommended!
This process requires a significant amount of NADH.
Therefore, the more NADH the body has available, the more protection the immune system can provide.
New scientific effects of Q1 + Q10 + selenium on the cardiovascular system
In recent years, a large number of Q10-containing preparations have appeared on the dietary supplement market, and more and more studies have been published on the active ingredient. In 1978, Peter Mitchell received the Nobel Prize for his research on the cellular effects of Q10.
To date, several placebo-controlled studies have supported the beneficial role of Q10 in the treatment of heart disease and in improving the quality of life of heart patients. Referring to these observations, the American Heart Association recommended the use of Q10 in the treatment of heart failure. The most reliable monographic summary of the clinical effects of Q10 was prepared by the Mayo Clinic in 2008, the latest version of which was published in 2013.
In 2007, Australian researchers (Rosenfeldt et al.) were able to prove the blood pressure-lowering effect of Q10, especially in patients with mild hypertension. Active ingredient tests also found vitamins, minerals and trace elements that can further enhance the effectiveness of Q10. One such substance is Q1.
In a study published last year, a Swedish medical team led by Professor Ulf Dahlström showed that the combined administration of organic selenium and Q10 significantly reduces cardiovascular mortality, especially among the elderly.1 They also drew attention to the fact that the natural active ingredient combination also increased the strength of the heart muscle, which was thus able to perform increased work.
In addition to diseases affecting the cardiovascular system, Q10 was also found to be beneficial in other diseases. In addition to the aforementioned Mayo monograph, Canadian researchers (Glover et al.) summarized in 2010 why the use of Q10 is beneficial in diseases where mitochondrial function is insufficient. The observations that observed the effectiveness of Q10 in Alzheimer's disease and Parkinson's disease patients are almost 10 years old.
Based on these observations, a series of clinical trials with several years of follow-up were approved in the USA, the evaluation of which is still ongoing today.
We can conclude that taking Q1 and Q10 + selenium is highly recommended in cardiovascular diseases!
Dr. Gyula Szigeti
Links:
1. Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U.: Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. May 22, 2012
Q10 - the guardian of cells
Today, we are exposed to many harmful effects, as a result of which free radicals are produced. These weaken our immune system and trigger inflammatory processes. If the inflammation is persistent, it can cause damage to cell membranes and DNA (the carrier of the gene pool), which is one of the important factors in the development of cancer cells.
Many free radicals are also produced during chemotherapy, so another serious side effect is the damage to our body's defense mechanisms. For this reason, it is important that strengthening the immune system is also an integral part of complex therapy, since weakened immune cells are unable to recognize and remove the constantly emerging defective cells, which also favors the re-formation of the tumor.
However, recent research has proven that coenzyme Q10 can effectively counteract the immune block.
Protects energy production
After recognizing that coenzyme Q10 can reduce the degree of mitochondrial damage caused by free radicals, Indian biochemists began researching the tumor-preventing potential of Q10. The test results showed that people suffering from cancer have much lower energy levels (little ATP is produced), which can clearly be attributed to the destruction of the mitochondria (the energy-producing center of the cells). Cancer patients develop pathological weight loss due to a lack of sufficient ATP in their bodies, which further worsens the general condition of patients with an already weakened immune system, and this is exacerbated by chemotherapy and radiation.
Research has investigated whether protecting the energy production of healthy cells with the help of Q10 would produce more ATP from the food consumed by cancer patients, and whether the excess energy would help the body fight the disease. Therefore, breast cancer was induced in rats with chemicals, and then they were treated with a substance containing riboflavin (vitamin B2), niacin (vitamin B6) and Q10 for 28 days. The energy production of animals that did not receive the vitamin was greatly impaired, while those that received the treatment showed better results. This research has proven that coenzyme Q10 has a protective function against cell-destructive effects.
Activates the immune system
1. American researchers discovered the immunostimulating effect of coenzyme Q10 back in the 90s – as it promotes the production of immunoglobulin-G and T4-helper cells, supports the recognition and removal of viruses and other foreign cells.
2. In 1994, women with terminal breast cancer in Denmark experienced a partial cure, although the tumor had already metastasized to the lymph nodes. During the treatment, the patients received a preparation containing coenzyme Q10, vitamins C and E, and essential fatty acids. Although their condition was very serious, not only did there not occur any deaths during the treatments, but the quality of life of the patients improved significantly.
3. Even more surprising was that 6 out of 32 women examined also experienced partial tumor regression! At that time, the researchers increased the dose of the drugs, and 2 months later, the mammography examination could not find any signs of a pathological process.
According to this, the bioenergetic activity of coenzyme Q10 during the treatment of breast cancer is outstanding, much higher than
Who knows what Q10 is?…
Q10 is a natural substance that is found in all tissues of our body and is closely linked to the processes of obtaining energy from nutrients in cells.
Its effect is enhanced by coenzyme Q1, because it activates Q10 during energy production.
It acts as a strong antioxidant: it neutralizes free radicals before they can destroy cell membranes and genes. Vitamins E, B2 and B6 also help in this.
Coenzyme Q10 has long been used to improve the functioning of the cardiovascular system and the brain.
Coenzyme Q10 has the ability to stop or slow down the growth of tumors.
It reduces the harmful side effects of chemotherapy: it inhibits the harmful effects of free radicals and inflammatory factors (cytokines) produced during treatment, while strengthening immune functions and energy levels in healthy cells.
Main effects of coenzymes Q1 and Q10:
It helps prevent cardiovascular diseases (primarily heart failure), and its use can also result in improvement in cases of already established disorders.
Heart attack: A study conducted on a small patient population found Q10 supplementation to be effective in improving the quality of life in the treatment of heart attack, if the therapy was started within 3 days.
High blood pressure: Based on the observations so far, it can be said that it can reduce blood pressure by 8-15 mmHg.
Angina: Clinical observations so far support that the use of Q10 reduces the occurrence of angina complaints and increases the cardiac effects of exercise.
It has a strong antioxidant effect in the body, which exerts its effect mainly in the mitochondria. It also protects against the oxidation of LDL cholesterol in the body.
Mitochondrial diseases: The use of Q10 and/or Q1 is justified based on the previously presented biochemical effect in the following diseases: myopathies and encephalomyopathies.
It also has an immune system-boosting effect, which is explained by the fact that immune cells are very energy-intensive, and coenzyme Q10 helps their energy production.
It can also help with chronic fatigue syndrome.
Alzheimer's disease: Clinical studies have shown that the use of Q10 and/or Q1 reduced the development and progression of dementia in Alzheimer's disease.
Parkinson's disease: Clinical studies have shown that the use of Q10 and/or Q1 reduced the symptoms of Parkinson's disease.
Muscular dystrophies: Q10 can help reduce the symptoms of muscular dystrophies and improve quality of life
reference Crane F.L., Hatefi Y., Lester R.I., Widmer C. (1957) Isolation of a quinone from beef heart mitochondria. In: Biochimica et Biophys. Acta, vol. 25, pp 220-221. Eighth International Symposium on Biomedical and Clinical Aspects of Coenzyme Q (1994) Littarru G.P., Battino M. , Folkers K. (Eds) The Molecular Aspects of Medicine, Vol. 15 (Supplement), pp S1-S294.Folkers K, Brown R, Judy WV, Morita M. Survival of cancer patients on therapy with coenzyme Q10. Biochem Biophys Res Commun. 1993;192:241-245. Folkers K., Langsjoen Per H.,Willis R., Richardson P., Xia L.,Ye C., Tamagawa H. (1990) Lovastatin decreases coenzyme Q levels in humans. Proc. Natl. Acad Sci. Vol. 87, pp.8931-8934.Folkers K., Vadhanavikit S., Mortensen S.A. (1985) Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. In: Proc. Natl. Acad. Sci., U.S.A., vol. 82(3), pp 901-904.Judy W.V., Hall J.H., Toth P.D., Folkers K. (1986) Double blind-double crossover study of coenzyme Q10 in heart failure. In: Folkers K., Yamamura Y. (eds) Biomedical and clinical aspects of coenzyme Q, vol. 5. Elsevier, Amsterdam, pp 315-323.Langsjoen P. H., Langsjoen P. H., Willis R., Folkers K. (1994) Treatment of essential hypertension with coenzyme Q10. In: Eighth International Symposium on Biomedical and Clinical Aspects of Coenzyme Q (1994) Littarru G.P., Battino M. , Folkers K. (Eds) The Molecular Aspects of Medicine, Vol. 15 (Supplement), pp S287-S294.Langsjoen P. H., Langsjoen, P. H., Folkers, K. (1989) Long term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. In: The American Journal of Cardiology, Vol. 65, pp 521 - 523. Langsjoen Per.H., Vadhanavikit S., Folkers K. (1985) Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. In: Proc. Natl. Acad. of Sci., U.S.A., vol. 82, pp 4240-4244. Mellors A., Tappel A.L. (1966) The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J. Biol. Chem., vol. 241, pp 4353-435 Mortensen S.A., Vadhanavikit S., Folkers K. (1984) Deficiency of coenzyme Q10 in myocardial failure. In: Drugs Exptl. Clin. Res. X(7) 497-502.